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arare subset of the MNDs begin and progress regionallybut never generalize to other areas of the body. Over 1 million new cases of cancer are diag-nosed each year and more than 1? million Americans dieyearly from cancer. In certain situations, the immune systemmust also recognize self in the context of non-self (Lo 2012).
Skeletal muscle ofthe deep perineal pouch surrounding the membranousurethra forms the external (voluntary) sphincter ofthe urethra. Thesefeatures, along with syntactic comprehension defi cits,are considered to be supportive of the clinical diagnosis(Gorno-Tempini et al., 2011; also refer to Table 9.12) andare important for distinguishing nonfluent PPA fromother variants (Mesulam et al., 2009), as in Figure 9.9.
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